Sell U-47700 Whatsapp:+8618903198932 Wechat: W18903198932
- 3.00 Dollar US$
- Published date: April 19, 2017
- Marshall Mill Road, Hampstead, Maryland, United States
Skype / Email:sales1 at hbmilin.com
Product Name: U-47700
Molecular Formula: C16H22Cl2N2O
Molar Mass: 329.27 g.mol-1
Appearance: White Powder
Delivery Time: within 3-5 hours after receipt of payment
Package: foil bag or Customized
Production Capacity: 100 Kilogram/Month
Storage: Store in Cool and dry .place, keep away fire.
Transportation: air express delivery
Payment : Money Gram, Western Union, T/T
MOQ: 10 Gram
U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selective agonist of the u-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the k-opioid receptor and has around 7.5 x the potency of morphine in animal models.
U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure-activity relationship of the scaffold.
Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety] until they discovered that U-47700 was the most active.
U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research.
U-47700 is selective for the u-opioid receptor, with various sources claiming 7.5x the potency of morphine.
Opioids exert their effects by binding to and activating the u-opioid receptor. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the u-opioid receptor set.
The way in which opioids structurally mimic these natural endorphins results in their euphoria, pain relief and anxiolytic effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.
Hebei Milin Biotechnology Co., Ltdis a professional supplier of medical intermediate and Pharmaceutical chemicals.
Milin produce customized intermediate products. Our quality controlled process ensures top quality product with every order shipping to anywhere in the world.
Quality First,Customer First,Reputation First is our important rules. Customer buy from us, not only because of reasonable price, high quality,most important because of trust. Mutually beneficial relationship build long-term business success.
Milin has a professional intermediate team.We are pleased to present you with information about our product and business.
We surely will meet your expectations.
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